Entamoeba histolytica contains an occludin-like protein that can alter colonic epithelial barrier function.
The exact mechanism by which Entamoeba histolytica disrupts the human colonic epithelium and invades the mucosa has yet to be clearly elucidated.E.histolytica produces a diverse array of putative virulent factors such as glycosidase, cysteine proteinases and amebapore that can modulate and/or disrupt epithelial barrier functions.However, Rugs it is